Treatment of sarcoidosis.
Identifieur interne : 002C00 ( Main/Exploration ); précédent : 002B99; suivant : 002C01Treatment of sarcoidosis.
Auteurs : O. Selroos [Finlande]Source :
- Sarcoidosis [ 0393-1447 ] ; 1994.
Descripteurs français
- KwdFr :
- Administration par inhalation, Administration par voie orale, Calendrier d'administration des médicaments, Facteurs temps, Glucocorticoïdes (administration et posologie), Glucocorticoïdes (usage thérapeutique), Humains, Prednisolone (usage thérapeutique), Sarcoïdose (traitement médicamenteux), Sarcoïdose pulmonaire (traitement médicamenteux), Voies d'administration de substances chimiques et des médicaments.
- MESH :
- administration et posologie : Glucocorticoïdes.
- traitement médicamenteux : Sarcoïdose, Sarcoïdose pulmonaire.
- usage thérapeutique : Glucocorticoïdes, Prednisolone.
- Administration par inhalation, Administration par voie orale, Calendrier d'administration des médicaments, Facteurs temps, Humains, Voies d'administration de substances chimiques et des médicaments.
English descriptors
- KwdEn :
- Administration, Inhalation, Administration, Oral, Drug Administration Routes, Drug Administration Schedule, Glucocorticoids (administration & dosage), Glucocorticoids (therapeutic use), Humans, Prednisolone (therapeutic use), Sarcoidosis (drug therapy), Sarcoidosis, Pulmonary (drug therapy), Time Factors.
- MESH :
- chemical , administration & dosage : Glucocorticoids.
- chemical , therapeutic use : Glucocorticoids, Prednisolone.
- drug therapy : Sarcoidosis, Sarcoidosis, Pulmonary.
- Administration, Inhalation, Administration, Oral, Drug Administration Routes, Drug Administration Schedule, Humans, Time Factors.
Abstract
Glucocorticosteroids represent the "drugs of choice" for treatment of sarcoidosis. Steroids can be given by all routes of administration. Daily therapy with oral steroids is most widely applied. Initial therapy should consist of prednisolone 30-60 mg/day or its equivalent. Alternate day therapy can be used during the maintenance phase. Inhaled steroids can also be tried during the maintenance phase for treatment of pulmonary sarcoidosis. Other drugs, which may be effective in sarcoidosis, and have a steroid-sparing capacity, are methotrexate, azathioprine, chlorambucil and cyclophosphamide. Chloroquine can be used for chronic skin lesions and potassium para-aminobenzoate may soften fibrotic lesions and keloids. Duration of treatment varies with the clinical situation; from between 6 and 18 months to lifetime. In principle, continuing signs of disease activity and functional impairment require continuing treatment. Determination of on-going activity may be a difficult task. Symptomatic patients with stage II-III pulmonary sarcoidosis, and many extrapulmonary manifestations of the disease, must be adequately treated. Symptom-free patients with deteriorating lung function and/or biochemical signs of disease activity also require treatment. Steroids are not indicated for pulmonary stage I disease (hilar lymphadenopathy) with or without erythema nodosum unless there are troublesome persistent chest symptoms (cough, pain, pressure symptoms) or arthralgia, oedema and pain of the legs.
PubMed: 8036353
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000530
- to stream PubMed, to step Curation: 000530
- to stream PubMed, to step Checkpoint: 000500
- to stream Ncbi, to step Merge: 001149
- to stream Ncbi, to step Curation: 001149
- to stream Ncbi, to step Checkpoint: 001149
- to stream Main, to step Merge: 002C59
- to stream Main, to step Curation: 002C00
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of sarcoidosis.</title><author><name sortKey="Selroos, O" sort="Selroos, O" uniqKey="Selroos O" first="O" last="Selroos">O. Selroos</name><affiliation wicri:level="1"><nlm:affiliation>Mjölbolsta Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8036353</idno><idno type="pmid">8036353</idno><idno type="wicri:Area/PubMed/Corpus">000530</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000530</idno><idno type="wicri:Area/PubMed/Curation">000530</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000530</idno><idno type="wicri:Area/PubMed/Checkpoint">000500</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000500</idno><idno type="wicri:Area/Ncbi/Merge">001149</idno><idno type="wicri:Area/Ncbi/Curation">001149</idno><idno type="wicri:Area/Ncbi/Checkpoint">001149</idno><idno type="wicri:doubleKey">0393-1447:1994:Selroos O:treatment:of:sarcoidosis</idno><idno type="wicri:Area/Main/Merge">002C59</idno><idno type="wicri:Area/Main/Curation">002C00</idno><idno type="wicri:Area/Main/Exploration">002C00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of sarcoidosis.</title><author><name sortKey="Selroos, O" sort="Selroos, O" uniqKey="Selroos O" first="O" last="Selroos">O. Selroos</name><affiliation wicri:level="1"><nlm:affiliation>Mjölbolsta Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital</wicri:regionArea></affiliation></author></analytic><series><title level="j">Sarcoidosis</title><idno type="ISSN">0393-1447</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation</term><term>Administration, Oral</term><term>Drug Administration Routes</term><term>Drug Administration Schedule</term><term>Glucocorticoids (administration & dosage)</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Prednisolone (therapeutic use)</term><term>Sarcoidosis (drug therapy)</term><term>Sarcoidosis, Pulmonary (drug therapy)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par inhalation</term><term>Administration par voie orale</term><term>Calendrier d'administration des médicaments</term><term>Facteurs temps</term><term>Glucocorticoïdes (administration et posologie)</term><term>Glucocorticoïdes (usage thérapeutique)</term><term>Humains</term><term>Prednisolone (usage thérapeutique)</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Sarcoïdose pulmonaire (traitement médicamenteux)</term><term>Voies d'administration de substances chimiques et des médicaments</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Glucocorticoids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Glucocorticoids</term><term>Prednisolone</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Glucocorticoïdes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Sarcoidosis</term><term>Sarcoidosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sarcoïdose</term><term>Sarcoïdose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Glucocorticoïdes</term><term>Prednisolone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Inhalation</term><term>Administration, Oral</term><term>Drug Administration Routes</term><term>Drug Administration Schedule</term><term>Humans</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par inhalation</term><term>Administration par voie orale</term><term>Calendrier d'administration des médicaments</term><term>Facteurs temps</term><term>Humains</term><term>Voies d'administration de substances chimiques et des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glucocorticosteroids represent the "drugs of choice" for treatment of sarcoidosis. Steroids can be given by all routes of administration. Daily therapy with oral steroids is most widely applied. Initial therapy should consist of prednisolone 30-60 mg/day or its equivalent. Alternate day therapy can be used during the maintenance phase. Inhaled steroids can also be tried during the maintenance phase for treatment of pulmonary sarcoidosis. Other drugs, which may be effective in sarcoidosis, and have a steroid-sparing capacity, are methotrexate, azathioprine, chlorambucil and cyclophosphamide. Chloroquine can be used for chronic skin lesions and potassium para-aminobenzoate may soften fibrotic lesions and keloids. Duration of treatment varies with the clinical situation; from between 6 and 18 months to lifetime. In principle, continuing signs of disease activity and functional impairment require continuing treatment. Determination of on-going activity may be a difficult task. Symptomatic patients with stage II-III pulmonary sarcoidosis, and many extrapulmonary manifestations of the disease, must be adequately treated. Symptom-free patients with deteriorating lung function and/or biochemical signs of disease activity also require treatment. Steroids are not indicated for pulmonary stage I disease (hilar lymphadenopathy) with or without erythema nodosum unless there are troublesome persistent chest symptoms (cough, pain, pressure symptoms) or arthralgia, oedema and pain of the legs.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Selroos, O" sort="Selroos, O" uniqKey="Selroos O" first="O" last="Selroos">O. Selroos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:8036353
|texte= Treatment of sarcoidosis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8036353" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |